Sivakumar Murugadoss
Dr. Sivakumar Murugadoss, a scientist at NILU Climate and Environmental Research Institute in Norway, specializes in in vitro toxicology and chemical safety. Holding a PhD in Biomedical Sciences from KU Leuven, he has investigated the health impacts of engineered nanomaterials through in vitro cell culture and animal models. His prior work at Sciensano and KU Leuven included contributions to European Horizon 2020 projects such as ALTERNATIVE and RISKGONE, where he developed Adverse Outcome Pathways (AOPs) and Integrated Approaches to Testing and Assessment (IATA) for cardiotoxicity and nanosafety. His current research focuses on advancing risk assessment and non-animal testing methods for regulatory use and the safety-by-design of chemicals. Dr. Murugadoss is an active participant in international conferences, fostering collaborations in environmental health and chemical safety.
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DISCUSSION "Monitoring the environment and its impact on health"
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Applying Adverse Outcome Pathways to evaluate the Health Impact of Environmental Chemicals
Adverse Outcome Pathways (AOPs) are scientific frameworks used to understand how harmful substances in the environment, such as chemicals and pollutants, can lead to health problems. By mapping the sequence of events that starts with exposure to a pollutant and leads to an adverse health effect, AOPs help scientists and policymakers see the "big picture" of how certain environmental chemicals might harm people’s health. For example, AOPs can show how air pollution may trigger biological changes that lead to respiratory issues like asthma or cardiovascular diseases. This knowledge aids in developing better safety measures and policies to protect public health from environmental hazards.
